This chapter discusses the methodology employed in the study, which investigated adolescent sexual behaviour and the impact of family dynamics on their sexual activities. The investigation adopted a sequential explanatory approach, harnessing both quantitative and qualitative data gathered from Cape Town, South Africa. The rationale behind this methodological choice is expounded upon in this chapter. The decision to employ mixed methods stems from the observation that prevailing studies on adolescent sexual behaviour often adopt a single-stranded approach, either quantitative or qualitative. In the context of this study, it becomes imperative to attain a comprehensive perspective on the intricacies of sexual behaviour, a feat accomplished through the synergistic deployment of both quantitative and qualitative methodologies. The chapter also details the strategies of data analysis.